Design and synthesis of chiral single-armed molecular tweezers derived fromα-hyodeoxycholic acid  

作　　者：Jian Wang Xiao Ya Yuan Jin Yue Wang Shu Hua Che 

机构地区：[1]Department of Chemistry and Chemical Engineering, Yibin University, Yibin 644007, China [2]College of Science, Chongqing Jiaotong University, Chongqing 400074, China [3]College of Chemistry, Sichuan University, Chengdu 610064, China

出　　处：《Chinese Chemical Letters》2009年第3期265-268,共4页中国化学快报（英文版）

基　　金：support from National Natural Science Foundation of China(No.20272038).

摘　　要：A novel type of molecular tweezers with different chiral center and cleft has been designed and prepared by using α- hyodeoxycholic acid as spacer and D/L-amino acid methyl ester as chiral arm attached at 3-position. Their structures were elucidated by ^1H NMR, FTIR and elemental analysis. Their recognition properties for various D/L-amino acid methyl esters were also investigated. The preliminary results indicated that these chiral single-armed molecular tweezers exhibited good recognition ability for D/L-amino acid methyl esters with high association constant （up to 5.24 × 10^3 L mol^-1）.A novel type of molecular tweezers with different chiral center and cleft has been designed and prepared by using α- hyodeoxycholic acid as spacer and D/L-amino acid methyl ester as chiral arm attached at 3-position. Their structures were elucidated by ^1H NMR, FTIR and elemental analysis. Their recognition properties for various D/L-amino acid methyl esters were also investigated. The preliminary results indicated that these chiral single-armed molecular tweezers exhibited good recognition ability for D/L-amino acid methyl esters with high association constant （up to 5.24 × 10^3 L mol^-1）.

关 键 词：α-Hyodeoxycholic acid Molecular tweezers SYNTHESIS RECOGNITION 

分 类 号：O641.6[理学—物理化学] TQ452.1[理学—化学]