Novel chiral thioureas for highly enantioselective Michael reactions of malonates to nitroalkenes  

作　　者：Li Jun Yan Quan Zhong Liu Xue Lian Wang 

机构地区：[1]Laboratory of Applied Chemistry and Pollution Control Technology, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China

出　　处：《Chinese Chemical Letters》2009年第3期310-313,共4页中国化学快报（英文版）

基　　金：support from Natural Science Foundation of China(No.20772097);Sichuan Provincial Science Foundation for Outstanding Youth(No.05ZQ026-008);Key Project of the Education Department of Sichuan Province(No.2006A081).

摘　　要：Highly efficient Michael addition reactions of malonates to nitroalkenes catalyzed by novel chiral thioureas derived from optically pure BINOL and amino acids are reported. Various trans-nitroalkenes reacted with malonates affording the desired products in up to 95% yield with excellent enantioselectivities （up to 97% ee）.Highly efficient Michael addition reactions of malonates to nitroalkenes catalyzed by novel chiral thioureas derived from optically pure BINOL and amino acids are reported. Various trans-nitroalkenes reacted with malonates affording the desired products in up to 95% yield with excellent enantioselectivities （up to 97% ee）.

关 键 词：Michael addition Thiourea Enantioselectivities Nitroalkene and malonate 

分 类 号：O621.256.7[理学—有机化学] O621.34[理学—化学]