Highly efficient synthesis of β-amino esters via Mannich-type reaction under solvent-free conditions using ZnCl_2 catalyst  

Highly efficient synthesis of β-amino esters via Mannich-type reaction under solvent-free conditions using ZnC12 catalyst

作　　者：Albert S.C.Chan 

机构地区：[1]School of Pharmaceutical Science,Sun Yat-Sen University

出　　处：《Chinese Chemical Letters》2009年第4期407-410,共4页中国化学快报（英文版）

基　　金：the financial support form National Natural Science Foundation of China(No.20472116).

摘　　要：β-Amino esters were synthesized via ZnCl2-catalyzed Mannich-type reaction of imines and malonate esters under solvent-free conditions in 6 min. The β-amino ester was converted into the corresponding aspartic acid derivatives.β-Amino esters were synthesized via ZnCl2-catalyzed Mannich-type reaction of imines and malonate esters under solvent-free conditions in 6 min. The β-amino ester was converted into the corresponding aspartic acid derivatives.

关 键 词：β-Amino esters Aspartic acid derivativates Mannich-type reaction SOLVENT-FREE Krapcho decarboxylation reaction Zinc chloride 

分 类 号：O621.251[理学—有机化学]