Two novel aconane-type diterpenes derived from C-nor-C_(19)-diterpenoid alkaloid  

作　　者：Xiang Li Shen Qiao Hong Chen Dong Lin Chen Feng Peng Wang 

机构地区：[1]Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu 610041, China [2]Second Hospital of Sichuan University, Chengdu 610041, China

出　　处：《Chinese Chemical Letters》2009年第4期431-434,共4页中国化学快报（英文版）

基　　金：support for this research was provided from the National Natural Science Foundation of China(No.30472075);the Excellent Ph.D.Dissertation Foundation of China(No.200367).

摘　　要：Two novel C-nor-B-homo aconane-type diterpenes 4 and 5, featuring a unique eight-membered ring system, were obtained by the treatment of C-nor-C19-diterpenoid alkaloid 3 with HNO2 in 8% and 21% yields, respectively. Structures of these two compounds were established based on the combination of spectroscopic data, including HRESIMS, 1D and 2D NMR data. A olausible mechanism for the formation of 4 and 5 is also presented.Two novel C-nor-B-homo aconane-type diterpenes 4 and 5, featuring a unique eight-membered ring system, were obtained by the treatment of C-nor-C19-diterpenoid alkaloid 3 with HNO2 in 8% and 21% yields, respectively. Structures of these two compounds were established based on the combination of spectroscopic data, including HRESIMS, 1D and 2D NMR data. A olausible mechanism for the formation of 4 and 5 is also presented.

关 键 词：C19-diterpenoid alkaloid C-nor-B-homo-aconane Rearrangement IMINE 

分 类 号：TQ153.12[化学工程—电化学工业] Q949.746.5[生物学—植物学]