月见草油为主要原料的软胶囊辅助降血脂减肥动物实验  

Experimental study on decreasing serum lipid and anti-obesity effects of traditional medicine soft capsule

作　　者：周月婵[1] 易传祝[1] 陈炜林[1] 胡怡秀[1] 胡余明[1] 邓彬彬[1] 

机构地区：[1]湖南省疾病预防控制中心,湖南长沙410005

出　　处：《中国热带医学》2009年第5期838-840,共3页China Tropical Medicine

摘　　要：目的探讨以月见草油、决明子、荷叶为主要原料制成的软胶囊辅助降血脂和减肥作用。方法以0.082g/kg·bw、0.163g/kg·bw、0.489g/kg·bw剂量的软胶囊给饲高脂饲料的大鼠灌胃1次/d,同时设立高脂对照组,连续灌胃30d后,测定大鼠的血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)水平,以观察其降血脂作用;每天以上述剂量给预防性肥胖模型大鼠灌胃,同时设立模型对照组,连续灌胃30d,定期称量体重,试验结束时称体重,剖腹取体脂(睾丸及肾周脂肪垫)并称重,计算脂/体比,以观察其减肥作用。结果降血脂实验中,与高脂对照组比较,0.489g/kg·bw剂量可显著降低饲高脂饲料大鼠血清甘油三酯水平及血清总胆固醇水平,且高剂量组动物体重及体重增长显著低于高脂对照组;减肥实验中,0.489g/kg·bw剂量组动物第三周末、试验末体重、体重总增重明显低于模型对照组,试验后体内脂肪重量明显低于模型对照组。差异有显著性(P<0.05或P<0.01)。结论以月见草油、决明子、荷叶为主要原料的软胶囊对动物具有辅助降血脂和减肥作用。Objective To investigate the lipid-lowering and anti-obesity effects of the soft capsule made of Evening primrose oil and Semen Cassiae and Lotus leaf. Methods The rats were divided into 4 groups （model group and 3 doseage groups） according to the serum TC level,the rats was given high lipid food. 0.082,0.163 and 0.489g/kg.bw doseage soft capsule was orally given successively for 30 days.Then the levels of serum TC and TG and HDL were observed. The anti-obesity effects of the soft capsule was used the preventive test of rats. Evening primrose oil soft capsule at doses of 0.082,0.163 and 0.489g/kg.bw was given preventively for 30 days and results were analyzed. Results The levels of TG and TC in serum of group treated at dose of 0.498 g/kg.bw were significantly reduced compared to the model group.3th week body weight , final body weight, body weight increased and body fat weight of the rats were significantly lower than the model group. Conclusion Eveningprimrose oil capsule possesses the assistant fuction of reducing blood lipid and anti-obesity.

关 键 词：月见草油 决明子 荷叶 辅助降血脂 减肥 

分 类 号：R285.5[医药卫生—中药学]