血清SOD水平在妊高征患者早期肾脏功能损害的诊断价值  

Value of detection of serum level of SOD in diagnosis of pregnancy-induced hypertension patients with early renal damage in the diagnosis

作　　者：赖金玉[1] 谭忠伟[1] 黎彩鹏[1] 

机构地区：[1]江门市妇幼保健院,广东江门529000

出　　处：《中国热带医学》2009年第5期880-881,共2页China Tropical Medicine

摘　　要：目的探讨过氧化损伤与妊高征早期肾功能损害的关系。方法对2008年1月．8月入住我院260例妊高征孕妇，进行血清中的超过氧化物歧化酶（SOD）检测，并将其与尿微量白蛋白（MAL）、β2-微球蛋白（β2-m）、24h总蛋白（TP）的相互关系进行分析。结果重度子痫前期组患者中，其SOD水平及尿MAL、β2-m、24h尿蛋白定量与妊娠对照组比较差异显著（P〈0．01），有统计学意义；轻度子痫前期组与妊娠对照组比较，血清SOD阳性率为76．13％，尿MAL、β2-m、24h蛋白定量阳性率分别65．91％、28．41％、47．73％；妊娠高血压组尿MAL、β2-m、24h尿蛋白定量与对照组无明显差异（P〉0．05），尿MAL、β2-m、24h尿蛋白定量阳性率分别15．70％、6．61％，12．40％，而血清SOD阳性率42．98％，与对照组相比也有统计学意义。结论检测血清SOD水平对妊高征患者早期肾脏功能损害有诊断价值。Objective To investiagte the correlation of peroxide injury with early pregnancy-induced hypertension and renal damage. Methods There 260 cases of pregnancy-induced hypertension were ivestigated from January 2008 to August 2008. The serum levels of superoxide dismutase（SOD）,urinary albumin（MAL）, β2-micro Globulin （β2-m）, 24 hours of total protein （TP）were detected. Results The levels of SOD in severe eclanlptism patients,urine MAL, β2-,24-hour urine protein were significantly differences compared with the control group （P〈0.01）; 2. in the light eclamptism group the, serum SOD-positive ratewas 76.13%; the positive ratesof urine MAL,β2-m,24-hour urine protein in pregnancy-induced hypertension group were 65.91%,28.41% and 47.73%.3. the positive rates of urine MAL, β2-m, 24-hour urine protein were 15.70% ,6.61%, 12.40%. Conclusion Detection SOD levels is valuable for diagnosis of pregnancy-induced hypertension patients with early renal damage.

关 键 词：妊高征 超过氧化物歧化酶 肾功能 

分 类 号：R714.246[医药卫生—妇产科学]