慢性心力衰竭患者血清C反应蛋白水平变化的临床意义  

Clinical Significance of Serum C-reaction Protein Change in Patients With Chronic Heart Failure

作　　者：肖红[1] 管秋玥[1] 唐继海[1] 陈春梅[1] 李欣[1] 

机构地区：[1]四川省人民医院草堂病区,四川成都610071

出　　处：《职业卫生与病伤》2009年第2期88-89,共2页Occupational Health and Damage

摘　　要：目的探讨血清C反应蛋白(CRP)水平变化在慢性心力衰竭患者中的治疗及预后评估的临床意义。方法采用免疫比浊分析方法测定78例慢性心力衰竭患者血清CRP,并与42例健康人群作对照。结果心功能(NYHA)I-Ⅳ级患者血清CRP较健康对照组明显升高,与心衰严重程度相关,差异有统计学意义(P<0.05)。心衰患者血清CRP与左室射血分数(LVEF)呈显著负相关。结论血清CRP在慢性心衰患者血清中明显升高,并能反映心功能恶化的程度。对心衰患者的治疗及预后评估具有重要的临床意义。Objective To investigate the change and clinical significance of C-reactive protein （CRP） in serum subjected to the patients with chronic heart failure （CHF） during the course of treatment and prognosis evaluation. Methods A total of 78 patients with chronic heart failure were selected, while 42 healthy people were assigned as control group. The level of CRP in serum was determined with immunoturbidimetrie assay. Results Compared with the healthy control group, heart failure patients of grades Ⅰ - Ⅲ（ according to New York Heart Association , NYHA） showed higher level of serum CRP. The level of serum CRP was positively relats to the severity of heart failure （P 〈 0. 05 ） , and negatively related to the the left ventricular ejection fraction （LVEF）. Conclusion Patients with chronic heart failure show higher level of serum CRP, and it reflects the extent of cardiac function impairment. The level of serum CRP Reveals important clinical significance in treatment and prognosis evaluation to the patients with chronic heart failure.

关 键 词：C反应蛋白 慢性心力衰竭 预后评估 

分 类 号：R541.6[医药卫生—心血管疾病]