雌激素与大鼠膝关节骨性关节炎相关性研究  

Correlational study on estrogen and osteoarthritis of knee joint in rats

作　　者：刘军[1] 李贵斌[1] 孙明宇[1] 谷贵山 

机构地区：[1]吉林大学第一医院骨关节一科,吉林长春130021

出　　处：《中国妇幼保健》2009年第12期1680-1682,共3页Maternal and Child Health Care of China

摘　　要：目的:研究雌激素与大鼠膝关节骨性关节炎(OA)病理改变的相关性,进一步研究OA的发病机理,对OA的预防与治疗提供参考。方法:成年雌性SD大鼠60只,随机分为假手术对照组(A组)、去势组(B组)、去势补充雌激素组(C组),第6周、10周各组随机取10只大鼠,观察动物膝关节大体改变,股骨髁、胫骨平台脱钙后切片,观察膝关节病理改变并行Mankin病理评分。结果:第6周、10周,B组可见轻中度OA改变,软骨变薄,颜色为淡黄色,Mankin病理评分分别为3.83±1.35、8.32±2.42,补充雌激素组较同期去势组病理改变轻,Mankin病理评分分别为0.94±0.31、3.62±1.42。结论:去势大鼠膝关节呈OA样病理改变,补充雌激素延缓OA的病理发展,雌激素在OA的病理进程中发挥重要作用。Objective：To explore the correlation between estrogen and osteoarthritis of knee joint in rats,investigate the pathological mechanism of osteoarthritis,provide some references for the prevention and treatment of osteoarthritis.Methods：60 female rats were divided into 3 groups ： group A（control group）,group B（the rats received ovariectomy）,group C（the rats received ovariectomy and estrogen treatment）.10 weeks after the treatments,the knees of 30 rats from 3 group were taken,condyles of femur and tibial plateau of rats were decalcified and sliced,the pathological changes were observed by Mankin pathological score.Results：In group B,the knees changed as osteoarthritis,the Mankid scores were（3.83±1.35） and（8.32±2.42）,respectively,while in group C the Mankin scores were（0.94±0.31） and（3.62±1.42）,respectively.Conclusion：Ovariectomy can induce osteoarthritis in female rats,but estrogen can delay the procedure,which plays an important role in the process of osteoarthritis.

关 键 词：雌激素 骨性关节炎 去势 

分 类 号：R684.3[医药卫生—骨科学]