成都地区乙型肝炎病毒基因型分布特点及其意义  

Distribution of hepatitis B virus genotpes in chengdu area and its clinical significance

作　　者：熊杰[1] 邹东花 白生华[2] 

机构地区：[1]成都军区总医院检验科,四川成都610083 [2]成都医学院第一附属医院,四川成都610500

出　　处：《四川医学》2009年第4期578-579,共2页Sichuan Medical Journal

摘　　要：目的调查成都地区乙型肝炎病毒(HBV)基因型分布特点及临床的关系。方法采用日本大和荧光定量PCR扩增仪对98例HBV DNA阳性标本进行基因型分型。结果HBV基因型在无症状携带者(ASC)组中的分布:B型60.0%(27/45),C型35.6%(16/45),BC型混合型4.4%(2/45),肝硬化、肝癌组中分布:B型26.42%(14/53);C型58.49%(31/53);BC混合型15.09%(8/53)。ASC组与肝硬化、肝癌组之间HBV基因型分布差异有统计学意义(χ2=11.94,P<0.01)。结论成都地区HBV感染者以基因型B、C型为主,且有少量BC型分布。ASC组以B型为主,肝硬化、肝癌组以C型为主。Objective To investigate the distribution of hepatitis B virus （HBV） genotypes in chengdu area and its clinical significance.Methods HBV genotypes of 98 pafients were measured by palymerase chain reaction （PCR）.Results The frequency of HBV genotypes B ,C and BC mixed genotype,in chronic asymptomafic HBV carries （ASC）group was 60.0% （27/45） ,35.6%（16/45） and 4.4% （2/45） ,and those ofHBV genotypes in liver cin＇hosic（LC） ,hepatocelluar carcinoma （HCC）gruoup was 26.42%（14/53）, 58.49%（31/53）ancl 15.19%（8/53）.There was a significant difference of the distribution of HBV genotypes betwenn the two groups （ χ^2 = 11.94, P 〈 0.01）. Conclusion HBV genotypes B and C were the major genotype of HBV infectious population in Chengdu area. The major type in Asc gruoup was genotype B, and in LC、HCC group it was genotype C.

关 键 词：乙型肝炎病毒 基因型 分布 

分 类 号：R512.62[医药卫生—内科学] R445.112[医药卫生—临床医学]