老年人孤立性、继发性房颤与KCNQ1多态性探讨  

Relationship beteen Lone Atrial Fibrillation or Secondary Atrial Fibrillation in Aged People and KCNQ1 Gene Polymorphisms

作　　者：梁旭[1] 杨纯玉[1] 徐笑洋[1] 李凤翘[1] 翟丽华[1] 

机构地区：[1]广东省深圳市人民医院老年病科暨南大学医学院第二附属医院,518000

出　　处：《中国误诊学杂志》2009年第14期3285-3286,共2页Chinese Journal of Misdiagnostics

摘　　要：目的:研究KCNQ1基因多态性与老年人孤立性、继发性心房颤动的关系。方法:选出老年人孤立性心房颤动患者15例,继发性房颤35例,无心房颤动同期住院患者65例为病房对照组,年轻健康体检对照组100例,应用基因芯片技术检测病例组与对照组KCNQ1基因多态性。结果:在深圳汉族人未发现KCNQ1 G等位基因,各研究组GS GG基因型频率为0。结论:本研究未发现KCNQ1 G等位基因,KCNQ1基因多态性与老年人孤立性、继发性心房颤动无相关性。Objective：To investigate the association of KCNQ1 gene polymorphisms with lone atrial fibrillation or secondary atrial fibrillation in aged people. Methods：The study included 15 lone atrial fibrillation patients and 35 sec ondary atrial fibrillation in aged people and 65 controls, 100 heathy controls. Gene chip was performed. Results ：KCNQ1 G alleles was scare. No statistically significant diffence was,observed in KCNQ1 genotype distribution. Conclusion： We have not found relationship between KCNQ1 gene polymorphisms and lone atrial fibrillation or secondary atrial fibrillation in aged people.

关 键 词：心房颤动/遗传学 多态现象 遗传 人类 老年人 

分 类 号：R541.7[医药卫生—心血管疾病]