老年危重患者抗生素相关性腹泻临床分析  

A clinical analysis of antibiotic associated diarrhea in critically ill elderly patients

作　　者：杜伟华[1] 李曙平[1] 钟雷[1] 

机构地区：[1]广州军区武汉总医院干部病房一科,湖北武汉430070

出　　处：《中华保健医学杂志》2009年第2期125-127,共3页Chinese Journal of Health Care and Medicine

摘　　要：目的探讨老年危重患者抗生素相关性腹泻(antibiotic associated diarrhea,AAD)的临床特点、主要相关因素及防治措施。方法对2004年12月～2007年12月住院的246例老年危重患者临床资料进行回顾性分析。结果246例老年危重患者中发生AAD者59例,发生率23.9%,其中≥80岁者41例,占69.5%。AAD发生前使用频率较高的抗生素依次为第三代头孢菌素(22.3%)、碳青酶烯类(20.4%)、克林霉素(13.6%)、第二代头孢菌素(10.7%)。AAD发生与使用抗生素种类、联合用药数量、疗程、疾病严重程度、采用医疗干预措施、高龄等因素相关。结论合理选择和使用抗生素是预防控制老年危重患者AAD的关键。Objective To investigate the clinical characteristic,the main risk factors of the antibiotic-associated diarrhea （AAD）in hospitalized critically ill elder patients and their prevention and therapeutic measures. Methods The clinical data of 246 critically ill elderly patients from Dec 2004 to Dec 2007 were studied retrospectively and analysed prospectively in AAD. Results 59 patients receiving antibiotics developed AAD ,prevalence ratio 23.9%. The risk factors of AAD were related to the kind. of using mix antibiotics and duration of treatment,number of co-prescribition, severity of disease and age. Conclusions Rational choice of antibiotic, and reasonal prescription of antibiotic were the key measures to prevent and control the AAD.

关 键 词：抗生素相关性腹泻 危重症 老年人 

分 类 号：R969.3[医药卫生—药理学]