保肝宁治疗慢性乙型肝炎肝纤维化的临床研究  

Clinical research of Baoganning against liver fibrosis after chronic hepatitis B

作　　者：贺松其[1] 张绪富[1] 吕志平[1] 安海燕[1] 

机构地区：[1]南方医科大学中医药学院,广州510515

出　　处：《中华中医药杂志》2009年第5期590-592,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然基金资助课题(No.30672769);广东省中医药局基金资助课题(No.1050128)

摘　　要：目的:观察保肝宁治疗慢性乙型肝炎肝纤维化的疗效。方法:选择慢性乙型肝炎肝纤维化患者228例,随机分为两组:对照组(100例)采用常规保肝治疗,治疗组(128例)在常规治疗的基础上口服保肝宁汤,观察治疗3个月前后两组患者临床症状、体征、肝纤维化血清标志物、纤溶系统指标及影像学指标的变化情况。结果:治疗组对肝炎后肝纤维化患者的临床症状、体征有明显的改善作用,治疗组治疗后低于对照组(P<0.01),两组证候积分治疗前后比较均见显著差异(P<0.01)。治疗组对血清肝纤维化标志物、纤溶系统指标及影像学指标均有明显的改善作用,临床疗效明显优于对照组(P<0.05或P<0.01)。结论:保肝宁具有明显改善肝炎肝纤维化患者的临床症状、体征的作用,且对阻断及逆转肝纤维化进程有一定疗效。Objective：To observe the effect of Baoganning in the treatment of liver fibrosis after chronic hepatitis B. Methods： 228 cases of such patients were randomly divided into two groups. The control group （100 cases） took the conventional treatment of liver protection, while the treatment group （128 cases） took Baoganning in addition. Then the study observed the clinical symptoms,syndromes, indicators of liver fibrosis, plasminogen activation system and imaging. Results： After treatment, the two groups of patients＇symptoms scores, indicators of liver fibrosis, plasminogen activation system and imaging were obviously improved, and the difference of comparison of matched pairs was significant（P〈0.01） .These changes of the treatment groups were superior to the control group,the difference between groups was significant（P〈0.05 or P〈0.01）. Conclusion： Baoganning could effectively improve the clinical symptoms and syndromes ,as well as block and reverse the process of liver fibrosis to a certain extent.

关 键 词：乙型肝炎 肝纤维化 中医药疗法 保肝宁 临床观察 

分 类 号：R259[医药卫生—中西医结合]