药物性肝病临床分析  

Clinical analysis of drug-induced liver disease

作　　者：杨颖[1] 王学清[1] 李岩[1] 

机构地区：[1]中国医科大学附属盛京医院消化内科,沈阳110004

出　　处：《实用药物与临床》2009年第2期82-84,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的探讨药物性肝病的病因、临床表现、治疗和预后。方法对2004年1月至2007年12月在我院住院的114例药物性肝病患者的临床资料进行回顾性分析。结果引起肝损伤的药物种类繁多,以中草药为首(41.23%),其次为抗结核药(15.79%)和非甾体抗炎药(14.04%)。临床表现无特异性,以乏力、厌食、恶心呕吐、腹胀多见;大部分病例(84.21%)预后较好,预后较好组血清总胆红素和碱性磷酸酶水平显著低于预后较差组(P<0.001)。结论重视药物性肝病的预防和早期诊断,尤其要警惕中草药的肝毒性。Objective To investigate the causative drugs, clinical manifestations, therapy and prognosis of drug-induced liver disease （DILD）. Methods The clinical data of 114 patients diagnosed with DILD from January 2004 to December 2007 were retrospectively analyzed. Results A variety of drugs could cause DILD, the common drugs were Chinese herbal medicine （41.23%）, antitubereulosis drugs （ 15.79% ） and non-steroid anti-inflammatory drugs （14.04%）. The main clinical manifestations of DILD were fatigue, anorexia, nausea, vomiting, abdominal distension, but was not specific. The prognosis of most cases （84.21%）was good, and the levels of serum total bilirubin and alkaline phosphatase in cases of better prognosis were lower than those in cases of worse prognosis（P〈0.001）. Conclusion The importance of the prevention, early diagnosis of DILD should be emphasized, especially the cases which were caused by Chinese herbal medicine.

关 键 词：肝损伤 中草药 预后 

分 类 号：R595.3[医药卫生—内科学]