布托啡诺和吗啡用于胆囊术后镇痛的效果比较  

Study on patient-controlled intravenous analgesia with butorphanol

作　　者：刘坤[1] 邱鹏[1] 孟凌新[1] 

机构地区：[1]中国医科大学附属盛京医院麻醉科,沈阳110004

出　　处：《实用药物与临床》2009年第2期87-88,共2页Practical Pharmacy and Clinical Remedies

摘　　要：目的观察布托啡诺用于胆囊切除术后的镇痛效果。方法选择60例拟全麻下行胆囊切除手术的患者,ASAⅠ～Ⅱ级,随机分成2组,吗啡组(M组)和布托啡诺组(B组),每组30例。术毕开始术后镇痛,持续48 h。分别于麻醉前、术毕及术后1、3、24 h采血,应用放射免疫分析法检测血清β-EP。结果两组患者镇痛评分(VAS)、血清β-内啡肽(β-EP)水平差异均无统计学意义(P>0.05)。结论吗啡和布托啡诺均可有效抑制术后应激反应程度,镇痛效果确切,适合用于术后镇痛。Objective Explore the effects of intravenous butorphanol for postoperative analgesia. Methods 60 patients undergoing cholecystectomy, ASA I-Ⅱ, were recruited and divided into 2 groups：morphine group（ group M,n =30） butorphanol group（group B,n =30） ,PICA lasted for 48 h. Peripheral venous blood was drawn before induction and at 1,3,24 h after operation. Serum levels of β-EP were measured with radioimmunoassay. Results There was no significant statistical significance among the two groups in VAS and the serum levels of β-EP（P〉0.05）. Conclusion Morphine, butorphanol can inhibit the stress response and analgesia effectively.

关 键 词：自控静脉镇痛 Β-内啡肽 布托啡诺 吗啡 

分 类 号：R614[医药卫生—麻醉学]