NF-κB信号转导通路与胰岛素抵抗  

NF-κB signal transduction pathway and insulin resistance

作　　者：金华[1] 陈名道[1] 杨颖[1] 

机构地区：[1]上海交通大学医学院瑞金医院内分泌代谢病科上海市内分泌代谢病研究所上海市内分泌代谢病临床医学中心,上海200025

出　　处：《上海交通大学学报（医学版）》2009年第4期461-464,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市教委基金(05BZ28);上海市优秀青年医学人才培养基金(2004);上海联合利华研究发展基金(2004)~~

摘　　要：核因子-κB(NF-κB)信号转导通路包括NF-κB、NF-κB抑制蛋白(IκB)和IκB激酶(IKK)。其中,NF-κB是一种重要的核转录因子,参与炎症反应、免疫反应、细胞凋亡及物质代谢等多种生物进程。IKK具有丝氨酸/苏氨酸激酶活性,能使多种蛋白的丝氨酸/苏氨酸残基磷酸化。NF-κB信号转导通路的活化与胰岛素抵抗的发生密切相关。文章就NF-κB在胰岛素抵抗发生中作用作一综述。Nuclear factor-kappa B（NF-κB） signal transduction pathway is comprised of NF-κB, inhibitory nuclear factor- kappa B（h（B） and inhibitory nuclear factor-kappa B kinase （IKK）. NF-κB is an important nuclear factor, which participates in various biological proceedings, such as inflammatory reaction, immune reaction, cell apoptosis and substance metabolism. IKK bears Ser/Thr kinase activity, which can phosphorylate the Ser/Thr residues of many proteins. Recently some studies have demonstrated that the activation of NF-κB transduction pathway is closely correlated to insulin resistance. This article reviews the research advances in the role of NF-κB transduction pathway in the pathogenesis of insulin resistance.

关 键 词：核因子-ΚB 核因子-κB抑制蛋白 核因子-κB抑制蛋白激酶 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌] R363.2[医药卫生—内科学]