不同服药方法对高血压患者疗效影响的研究  

Study of Different Medication on Treatment of Patients with Essential Hypertension

作　　者：崔立然[1] 翟伟宇[1] 刘树民[2] 

机构地区：[1]齐齐哈尔医学院第一附属医院,齐齐哈尔161000 [2]黑龙江中医药大学中医药研究院

出　　处：《中国药师》2009年第5期566-569,共4页China Pharmacist

摘　　要：目的:探讨不同服药方法对于高血压治疗有效性和平稳性的影响。方法:采用随机、平行对照设计。对90例Ⅱ级及以上高血压患者,随机分为早晨服用硝苯地平控释片(拜新同)和缬沙坦(代文)组(甲组),早晨服缬沙坦晚上服硝苯地平控释片组(乙组),早晨服硝苯地平控释片晚上服缬沙坦组(丙组),患者均于服药前及服药后2周进行动态血压监测求得平滑指数等指标。结果:服药两周后,夜间、24h平均收缩压的下降值甲组小于乙、丙两组,P<0.01,夜间、24h平均动脉压的下降值甲组小于乙组,P<0.05,甲组小于丙组,P<0.01。甲组夜间、24h平均收缩压平滑指数小于乙、丙两组,P<0.01。夜间、24h平均动脉压平滑指数甲组小于乙组,P<0.05,甲组小于丙组,P<0.01,夜间舒张压平滑指数甲组小于乙组,P<0.01,甲组小于丙组,P<0.05。结论:联合用药降压效果显著,早晚分次服药较早晨顿服两种药能更有效控制夜间血压及使夜间及24h血压下降更平稳。Objective： To study the efficacy and stability of different medication on treatment of essential hypertension. Method： Ninety patients with essential hypertension were randomly divided into 3 groups. The first group was taken valsartan（Diovan） and nifedipine together in the morning; the second group was taken valsartan in the morning and nifedipine in the evening;the third group was taken nifedipine in the morning and valsartan in the evening. Ambulatory blood pressure monitoring （ABPM） was performed from first day to two weeks later. Result： The decreased values of night time and 24 hours mean systolic blood pressure of group 1 was smaller than those of group 2 and group 3（P 〈0.01 ）. The decreased values of night time and 24 h mean arterial blood pressure of group 1 were smaller than these of group 2（P 〈0.05）and smaller than group 3（P 〈0.01 ）. There was no statistical difference between group 2 and group 3. The smoothness index of mean systolic,mean arterial blood pressure at night time of group 1 were lower than these of group 2 and group 3 （P 〈 0.01 ）. The smoothness index of twenty-four hour mean systolic and mean arterial blood pressure of group 1 were lower than these of group 2 （P 〈 0.05 ） and smaller than group 3 （ P 〈 0.01 ）, the smoothness index of diastolic at night time of group 1 was lower than that of group 2（P 〈0.01 ） and smaller than group 3（P 〈0.05）. Conclusion： The efficacy of reduce blood pressure is significantly by combination of medication, taking drugs in the morning and evening separately is more efficacy than two drugs taking together in the morning to control night time blood pressure, the former makes blood pressure more steady in night time and 24 hours.

关 键 词：服药方法 高血压 有效性 平稳性 

分 类 号：R544.1[医药卫生—心血管疾病]