纳米乳在药剂学中的研究进展及其应用  

Research Progress on Application of Nanoemulsions in Pharmaceutics

作　　者：胡宏伟[1,2] 李剑勇[1] 吴培星[1] 周绪正[1] 张继瑜[1] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所新兽药工程重点开放实验室,兰州730050 [2]甘肃农业大学动物医学院,兰州730070

出　　处：《湖北农业科学》2009年第3期747-750,共4页Hubei Agricultural Sciences

基　　金：国家高技术研究发展计划("863"计划)重大项目(2006AA10A203);中央级公益性科研院所基本科研业务费专项资金项目(BRF070405)

摘　　要：综述纳米乳作为新型药物载体的优势,形成纳米乳的各组分发挥的作用以及不同给药途径在药剂学方面的应用状况。查阅大量近年来国内外的相关文献并进行归纳、总结。结果表明,纳米乳在透皮给药、口服给药、黏膜给药、注射给药等多个给药途径中较之普通乳剂有明显的优势。纳米乳作为一种新型药物载体系统具有对难溶性药物强大的增溶作用,还具有明显的缓释作用、靶向性及较高的生物利用度等优点,在药剂学领域有广阔的应用前景。The advantages of nanoemulsion as a novel vehicle of the drug delivery system, the roles of the ingredients and the application of various methods of administration in pharmaceutics were systematically reviewed. The application of nanoemulsions in drug delivery systems including transdermal, mueosal, oral and injection delivery systems was better than ordinary emulsions. Nanoemulsions, with a very good prospect in pharmaceutics in the future, had many good characters such as good solubilization to indissolvable drugs, delayed release, targets and high bioavailability.

关 键 词：纳米乳 表面活性剂 给药系统 生物利用度 

分 类 号：S853.7[农业科学—临床兽医学] O647.2[农业科学—兽医学]