心肌细胞电生理建模进展  

Progress on Cardiac Cell Electrophysiological Modelling

作　　者：黎捷[1] 王宽全[1] 袁永峰[1] 左旺孟[1] 吕伟刚[1] 

机构地区：[1]哈尔滨工业大学计算机学院生物计算技术研究中心,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2009年第8期1594-1597,共4页Progress in Modern Biomedicine

基　　金：国家863计划资助:多尺度拟心脏解剖和功能建模与可视化技术研究(2006AA01Z308);国家自然科学基金项目:e-heart仿真平台及关键技术研究(60571025)

摘　　要：心脏兴奋收缩的微观基础是心肌细胞的电生理活动,心肌细胞的电生理模型在解剖实验基础上提供了更为全面有力的数据,是研究心肌细胞最有效的方法之一。近年来单细胞意义上的电生理模型越来越精细,使得心肌细胞的工作原理以不同角度在微观领域得以进一步阐述。本文就不同时期有代表性的模型进行了研究和比较,总结了这一领域的发展,并对发展趋势作了进一步的展望。One essential basis of the heart excitation and contraction in microcosmic level is the electrophysiological activities of the cardiac cell. Cardiac cell electrophysiological model supports more comprehensive data on the basis of anatomical experiments, and is one of the most efficient methods in heart function and dysfunction research. Recently, the electrophysiological models are more and more detailed in the single cell level, which consequently in depth elucidates the mechanism of the cardiac cell from different aspects. The progress on the electrophysiological model of the cardiac cell is described, a summarization in this field and a discussion of trends is concluded.

关 键 词：心肌细胞 电生理建模 模型 

分 类 号：R331.38[医药卫生—人体生理学] TP39[医药卫生—基础医学]