AnnexinⅡ在特发性间质性肺炎肺组织中的表达及可能作用的初步探讨  

The expression and probable role of Annexin Ⅱ in idiopathic interstitial pneumonia

作　　者：陈国勤[1] 顾莹莹[1] 莫明聪[1] 冼慧仪[2] 廖东江[2] 李时悦[2] 

机构地区：[1]广州医学院附属第一医院病理科,广东广州510120 [2]广州医学院附属第一医院呼吸病研究所,广东广州510120

出　　处：《国际内科学杂志》2009年第4期187-188,195,F0003,共4页International Journal of Internal Medicine

基　　金：广州市科技计划项目(2006J1-C0021)

摘　　要：目的检测膜联蛋白Ⅱ(AnnexinⅡ)在特发性间质性肺炎(IIP)中的表达情况,探讨AnnexinⅡ的可能作用机制。方法采用免疫组织化学技术检测IIP及正常肺组织中AnnexinⅡ的表达情况。结果AnnexinⅡ主要表达于肺泡上皮细胞、肺泡间隔纤维细胞的胞浆中。在正常肺组织中,AnnexinⅡ为弥漫的棕褐色强阳性表达,而在IIP肺组织中,为黄色中至弱阳性表达。免疫组织化学染色强度评分结果显示,普通型间质性肺炎组肺组织中AnnexinⅡ的表达强度低于非特异性间质性肺炎组。结论AnnexinⅡ在特发性间质性肺炎中起重要的作用,可能是作为肺纤维化判断预后的重要指标。Objective To detect the expression of Annexin Ⅱ in idiopathic interstitial pneumonia（IIP）, and to explore the role of Annexin Ⅱ in mechanisms of IIP. Methods The expression of Annexin Ⅱ in IIP and normal lung tissues was detected by immunohistochemistry. Results It showed that Annexin Ⅱ were mainly located in the cytoplasm of alveolar epithelial ceils, fibroblast in alveolar interval Furthermore, the score of Annexin Ⅱ expression in nonspecific interstitial pneumonia group was significantly higher than that in usual interstitial pneumonia group. Conclusion Annexin Ⅱ may play important roles in pathogenesis of IIP, and could be a useful prognostic indicator of IIP.

关 键 词：特发性间质性肺炎 AnnexinⅡ 免疫组织化学 

分 类 号：R563.1[医药卫生—呼吸系统]