Th17细胞分化及与疾病关系的研究新进展  

Progress of researches on differentiation of Th17 and its relationship with diseases

作　　者：王中华[1] 周燕斌[1] 

机构地区：[1]中山大学附属第一医院呼吸内科,广东广州510080

出　　处：《国际内科学杂志》2009年第4期242-245,共4页International Journal of Internal Medicine

摘　　要：Th17细胞是一类新型CD4+T细胞,它与Th1、Th2、Tregs细胞一起构成了CD4+T细胞的4个主要亚群。它由初始T细胞在转化生长因子(TGF)-β和白细胞介素(IL)-6联合诱导下分化而来。这一分化过程在细胞和分子水平都受到精细的调节。IL-17是Th17细胞最主要的分泌产物,在自身免疫性疾病、某些感染性疾病以及肿瘤中起到重要的调节作用。因此Th17细胞及其相关因子可能为此类疾病的治疗提供新的靶点和途径。T helper 17 cells（Th17）, a new type of CD4^＋T cells, constitute the main subsets of CD4^＋T cells together with Thl, Th2 and Treg cells. Transforming growth factor-β combining with interleukin（IL） -6 can induce naive CD4^＋T cells to differentiate into Th17. The differentiation process can be precisely regulated on cell ular and molecular levels. IL-17 is the main secretory product of Th17, which plays important regulatory roles in autoimmune diseases,infectious diseases and tumors. Therefore, Th17 and its related cytokines may provide promising targets and approaches for the treatment of diseases.

关 键 词：TH17细胞 白细胞介素-17 分化 疾病 

分 类 号：R392.12[医药卫生—免疫学]