FGFR4对胆汁酸代谢的调控作用  

The role of FGFR4 in the regulation of bile acid metabolism

作　　者：姜远[1] 俞春东[1] 

机构地区：[1]厦门大学生命科学学院,厦门361005

出　　处：《生命的化学》2009年第2期202-205,共4页Chemistry of Life

基　　金：福建省自然科学基金计划项目(2008J0110)资助

摘　　要：成纤维细胞生长因子受体4(fibroblast growth factor receptor4,FGFR4)是一种能够介导成纤维细胞生长因子(FGF)信号传导的细胞表面跨膜酪氨酸激酶受体。在成熟肝实质细胞中,FGFR4在其配体FGF15或FGF19的刺激下通过激活JNK信号通路来抑制胆汁酸合成限速酶胆固醇7α-羟化酶的表达,进而抑制胆汁酸的合成。本文介绍FGFR4及其配体在胆汁酸代谢过程中的作用及其相关机制方面的研究进展。Fibroblast growth factor receptor 4 （FGFR4） is a transmembrane tyrosine kinase receptor which mediates the transduction of FGF signals to the cytoplasm. The expression of CYP7A1, a rate-limiting enzyme in bile acid synthesis, is repressed by FGFR4 and its ligands, FGF15 or FGF19, through activation of JNK signaling pathway in mature hepatocytes. This review presents the research progress of the role of FGFR4 in the regulation of bile acid metabolism.

关 键 词：成纤维细胞生长因子受体4 胆汁酸 代谢调控 

分 类 号：Q591.5[生物学—生物化学]