胞膜小窝/小窝蛋白-1复合体的细胞信号转导  

Signal transduction of caveolae/caveolin-1

作　　者：谌赟[1] 秦旭平[1] 

机构地区：[1]南华大学药物药理研究所,衡阳421001

出　　处：《生命的化学》2009年第2期214-217,共4页Chemistry of Life

摘　　要：胞膜小窝(caveolae)是细胞膜表面特化的泡状内陷微区,由胆固醇、鞘脂和蛋白质组成,小窝蛋白-1(caveolin-1)是其标志性蛋白。胞膜小窝是一个信号转导的整合器,许多信号分子集结于此。大多数情况下,小窝蛋白-1能与其调节的信号分子蛋白结合,并起到负调控作用;在血管平滑肌细胞分化、增殖和动脉粥样硬化等多种病理和生理过程中起到重要调节作用。Caveolae are specific flask-shaped invaginations at the plasma membrane, and consist of cholesterol, sphingolipid and proteins. Its marker proteins are caveolins. Caveolae are the integrations of cell signal transduction, in which many signaling molecules aggregate. In most cases, caveolins can recruit signaling molecule proteins and have negative regulative effect. This effect involves in the regulations of vascular smooth muscle cell differentiation, proliferation, and atherosclerosis.

关 键 词：胞膜小窝 小窝蛋白 信号转导 

分 类 号：Q2[生物学—细胞生物学]