组织因子途径抑制物2的研究进展  

Research Progress in Tissue Factor Pathway Inhibitor-2

作　　者：苗海卫（综述）[1] 罗心平（审校）[2] 

机构地区：[1]上海市复旦大学附属金山医院心内科,上海200540 [2]上海市复旦大学附属华山医院心内科,上海200040

出　　处：《医学综述》2009年第9期1286-1288,共3页Medical Recapitulate

摘　　要：组织因子途径抑制物2（TFPI-2）是相对分子质量为32×10^3的基质相关的库尼（Kun itz）型丝氨酸蛋白酶抑制剂。TFPI-2大部分来自细胞外基质中的内皮细胞（60%～90%）。在体内,TFPI-270%～75%与细胞外基质结合。TFPI-2被认为在细胞外基质的降解和重塑中起重要作用。目前来说TFPI-2在生理、病理中的作用还没有准确完整结论,但在许多方面已经有了使人感兴趣的进展,值得进一步的研究。本文对相关的研究予以总结。Tissue factor pathway inhibitor-2 （TFPI-2） is a matrix-associated Kunitz-type domains serine protinase inhibitor with molecular mass about 32 × 10^3. 60% to 90% TFPI-2 produced by endothelial cells. AND 70% to 75% TFPI-2 combined with ECM. TFPI-2 is thought to play an important role in the regulation of extracellular matrix digestion and remodeling. Although there is not precise result about the physiology and pathology of TFPI-2. The synthesis of TFPI-2 is related to numerous pathophysiological processes. The recent progress in the related reasearch is reviewed in this article.

关 键 词：组织因子途径抑制物2 细胞外基质 金属蛋白酶 转移 

分 类 号：Q469[生物学—生理学]