氧化型低密度脂蛋白与动脉粥样硬化研究进展  

Study Progress of Oxidized Low Density Lipoprotein and Atherosclerosis

作　　者：王建礼[1] 徐兴华[2] 林娜[2] 

机构地区：[1]济宁医学院病理生理学教研室,山东济宁272013 [2]济宁医学院机能实验室,山东济宁272013

出　　处：《医学综述》2009年第9期1307-1310,共4页Medical Recapitulate

摘　　要：氧化型低密度脂蛋白是一种重要的致动脉粥样硬化脂蛋白,作为动脉粥样硬化的独立危险因素,在动脉粥样硬化的发生、发展过程中具有重要的作用。它可诱导血管内皮细胞损伤,诱导单核细胞与内皮细胞的黏附,并在泡沫细胞的形成及影响斑块稳定性方面发挥作用。本文就近年来氧化型低密度脂蛋白与动脉粥样硬化关系的研究予以综述。Oxidized low density lipoprotein is a very important lipoprotein that can induce atherosclerosis, as the independent risk factor of atherosclerosis, it plays an important role in the genesis and development of athemsclerosis. It can induce the injure of vascular endothelial cell and the adhesion of monocytes and en- dothelial cell. It also play a part in the formation of foam cell and effecting the stability of plaque. This article reviews the study progresses of the relationship of oxidized low density lipoprotein and athemselerosis.

关 键 词：氧化型低密度脂蛋白 动脉粥样硬化 泡沫细胞 基质金属蛋白酶 

分 类 号：R589[医药卫生—内分泌]