造影剂相关性肾病患者尿液β2-MG、NAG及KIM-1的变化  

The Changes of Urinary β2-microglobin,N-acetyl-beta-D-glucosaminidase and Kidney Injury Molecule-1 in Patients with Contrast Agent-induced Nephropathy

作　　者：徐向明[1] 何坚[1] 贺军[1] 

机构地区：[1]广东省增城市新塘医院急诊科,增城511340

出　　处：《热带医学杂志》2009年第4期412-413,397,共3页Journal of Tropical Medicine

摘　　要：目的通过检测造影剂相关性肾病患者尿液中β2微球蛋白(β2-MG)、N-乙酰-β-D-氨基葡萄糖苷酶(NAG)及肾损伤分子1(KIM-1)的水平,了解β2-MG、NAG及KIM-1在造影剂相关性肾病患者中的改变及其与肾功能之间的关系。方法收入49例造影剂相关性肾病患者,同时收入52例健康志愿者,以ELISA法分别检测其尿液中的β2-MG、NAG及KIM-1水平,分析其与患者肾功能之间的关系。结果造影剂相关性肾病患者尿液中β2-MG、NAG、KIM-1分别为(594.62±87.93)mg/L、(24.52±4.64)U/L、(4.68±0.83)ng/mL,均高于健康对照组[β2-MG(108.16±10.55)mg/L,NAG(8.74±1.75)U/L,KIM-1(0.28±0.10)ng/mL],差异有统计学意义(P均<0.05);患者组的肌酐清除率Ccr为(25.09±7.50)ml/min,低于健康对照组的(83.75±33.84)ml/min,差异亦有统计学意义(P<0.05)。结论造影剂相关性肾病患者尿液中β2-MG、NAG及KIM-1水平较健康对照组明显升高,反映了肾小管的损伤情况,可作为造影剂相关性肾病患者肾功能的检测指标。Objective To explore the relationship between the changes of urinary β2-microglobin （β2-MG）, N-acetyl-beta-D-glucosaminidase （NAG） and kidney injury molecule-1 （KIM-1） in patients with contrast agentinduced nephropathy （CIN） by analyzing the level of urinary β2-MG, NAG and KIM-1. Method 49 cases of CIN patients and 52 cases of healthy volunteers were enrolled into the study. The levels of urinary β2-MG, NAG and KIM-1 were determined by ELISA. Result The level of β2-MG （594.62±87.93）mg/L, NAG （24.52±4.64）U/L and KIM-1 （4.68± .83）ng/mL in CIN patients was significant higher than the healthy subjects [β2-MG （108.16± 10.55）mg/L,NAG （8.74±1.75）U/L,KIM-1 （0.28±0.10）ng/mL]. And the level of creatine of CIN patients （25.09±7.50）ml/min was significant lower than the healthy control subjects （83.75±33.84） ml/min. Conclusion The level of urinary β2-MG, NAG and KIM-1 is elevated in CIN patients, indicating the impairment of tubular function. β2-MG, NAG and KIM-1 may be useful indicators for the monitoring of kidney function in CIN patients.

关 键 词：造影剂相关性肾病 β2微球蛋白 N-乙酰-Β-D-氨基葡萄糖苷酶 肾损伤分子1 

分 类 号：R692[医药卫生—泌尿科学]