STAT3信号转导通路及肿瘤治疗的方法  

STAT3 Signal Transduction Pathway and Methods for Tumor Therapy

作　　者：李庆伟[1] 褚丹[1] 王继红[1] 

机构地区：[1]辽宁师范大学生命科学学院,辽宁大连116029

出　　处：《沈阳师范大学学报（自然科学版）》2009年第2期230-235,共6页Journal of Shenyang Normal University:Natural Science Edition

基　　金：国家高技术研究发展863计划资助项目(2007AA09Z428);大连市科技攻关项目(2005E11SF067);大连市重大科技攻关项目(2007E11SF051)

摘　　要：STAT3是一类由750800个氨基酸组成的DNA结合蛋白，有泖三种亚型，它因可介导细胞的恶性转化而被确认为癌基因，STAT3在早期胚胎发育和骨髓细胞的分化中发挥着不可缺少的重要作用，此外它还参与了肿瘤的增殖、分化、血管生成、侵袭转移和免疫逃避等生理功能的调控。与STAT3相关的几条信号转导通路特别是Jak—STAT3信号转导通路在多种肿瘤细胞中均有激活，体内外阻断或抑制肿瘤细胞中STAT3的信号通路可抑制细胞恶性增殖和存活，并诱导细胞凋亡，而对正常细胞却无影响。Signal transducers and activators of transcription （STAT3） composed of 750-800 amino acid is a DNA binding protein and has αβγ subtypes. Since STAT3 can induce cells to malignant transformation, it has been identified as an oncogene. STAT3 plays an important role in early embryonic development and differentiation of marrow cells. In addition, it also regulate the proliferation, differentiation, angiogenesis, invasion metastasis and immune evasion. A few signal transduction pathway related to STAT3, especially JAK-STAT3 signal transduction pathway, are activated in most tumor cells. We can prevent tumor cells from malignant proliferation and induces to apoptosis by blocking or inhibiting STAT3 signal transduction pathway in vivo and in vitro. However it makes no effects on normal cells. GRIM-19 as a specific inhibitory protein can inhibit STAT3-dependent transcription and expression of target gene. GRIM-19 and its target gene STAT3 as a novel biological label can be used to screening and prognostic evaluation. Moreover, it provides a new research direction for target therapy of oncogenes.

关 键 词：STAT3 信号通路 肿瘤 

分 类 号：Q781[生物学—分子生物学]