瘦素与冬眠动物冬眠前能量积累和入眠的关系  

Relationship Between Leptin and Hibernator's Energy Accumulation and Hibernation Entering

作　　者：官桂红[1,2] 

机构地区：[1]沈阳师范大学化学与生命科学学院,辽宁沈阳110034 [2]沈阳师范大学实验中心,辽宁沈阳110034

出　　处：《沈阳师范大学学报（自然科学版）》2009年第2期236-240,共5页Journal of Shenyang Normal University:Natural Science Edition

基　　金：国家自然科学基金资助项目(30770337)

摘　　要：瘦素(Leptin)是在1994年鉴定的由肥胖基因(ob基因)编码的产物,是一种分子量为16 000道尔顿的蛋白质,主要由白色脂肪组织合成,其受体后机制是通过酪氨酸蛋白激酶(Januskinases,JAK)和转录信号转导物及激活剂(signal transducers and activators of transcription,STAT)途径实现的,主要活化JAK2-STAT3途径,其功能主要是抑制摄食和调节机体能量代谢,可使体重下降。许多实验证明,血浆瘦素与体脂之间存在密切关系。瘦素与肥胖的水平有关,因此瘦素似乎是一个重要的调解成分。有关调节冬眠动物瘦素分泌和功效的知识为理解人类与其他非冬眠种类正常和异常的肥胖调节提供了有用的信息。Leptin is the product of the obese （ob） gene identified in 1994. It is a protein with a molecular size of 16 kDa that is synthesized mainly in white adipose tissue . Its receptor＇ s mechanisim was achieved by Janus kinases （JAK） and signal transducers and activators of transcription（STAT） pathway, mainly active the JAK2-STAT3 pathway. Leptin plays an essential role in inhibiting food intake and regulating the energy metabolism and reducing the body weight. Many experiments have approved plasma leptin levels are highly correlated with adipose tissue mass. Leptin seems being a main regulator, because of the relation between leptin and fat level. Knowledge about the regulation of leptin seceretion and efficacy during the hibernators could provide information useful for understanding normal and abnormal regulation of adiposity in humans and other nonhibernating species.

关 键 词：瘦素 能量 冬眠 

分 类 号：Q57[生物学—生物化学]