老年高血压患者血压昼夜节律特点及药物干预的研究  

Study on the circadian rhythm and drug intervention in elderly hypertension patients

作　　者：梁积英[1] 潘文晶[1] 莫永秀[1] 史文[1] 杨立新[1] 苏卫红[1] 李维[1] 

机构地区：[1]广西壮族自治区江滨医院心内科,南宁市530021

出　　处：《内科》2009年第2期191-193,共3页Internal Medicine

摘　　要：目的研究老年高血压患者24 h动态血压昼夜节律特点以及培哚普利干预的疗效。方法对60例老年高血压患者(观察组)和100例非老年高血压患者(对照组)进行动态血压监测(ABPM);观察组患者给予口服培哚普利,于服药前后及检测24 h动态血压(ABPM)、血脂、血糖、肝肾功能等。结果观察组患者昼夜节律性和全天及昼间舒张压低于对照组(P<0.0 5)。夜间收缩压和脉压差均高于对照组(P<0.001)。观察组口服培哚普利4周后,24 h、白昼、和夜间血压均值均比治疗前明显下降(P<0.01),夜间血压比白昼血压均值下降明显(P<0.01)。结论老年高血压患者血压昼夜节律降低、动脉压差增大,白天舒张压降低、夜间收缩压增高、脉压差增大是老年高血压病血压昼夜节律特点。培哚普利能24 h缓慢降低老年高血压患者血压尤其夜间收缩压,改善非杓型血压昼夜节律。Objective To investigate the 24 hours circadian rhythm of ambulatory blood pressure trend and the Perindoprill effect in elderly hypertension patients. Methods Ambulatory blood pressure monitoring （ABPM） was performed on 60 elderly hypertension patients （ ob- served group） and 100 non-aged elderly hypertension patients （ control group）, the patients of observed group were tested bloed-lipoids, blood-sugar,liver function, renal function and 24 hours ABPM before and after having Perindoprill. Results The circadian rhythm was decline and diastolic blood pressure of the whole day in patients of observed group was significant lower than those in control group （ All P 〈0.05 ）. Systolic blood pressure and pulse pressure at night in observed group were higher than those in control group （ All P 〈 0.001 ）. Mean blood pressure in 24 hours, during the day and at night in the patients of observed group were decline dramatically after taking Perindopril for four weeks （P 〈0.01 ）. Mean blood pressure at night was decline more than that during the day （ P 〈 0.01 ）. Conclusion There are following characteristics in elderly hypertension patients：circadian rhythm being decline and pulse pressure being increase and diastolic blood pressure during the day being decline and systolic blood pressure at night being increase. Perindoprill have induced blood pressure of aged hypertensive patient decreasing slowly in 24 hours especially in systolic blood pressure at night and lead to circadian rhythm of non-dipper hypertensive patients improve.

关 键 词：高血压 老年人 动态血压监测 药物干预 

分 类 号：R544.1[医药卫生—心血管疾病]