胃炎一号方对实验性慢性萎缩性胃炎大鼠SOD、MDA的影响  

Effects of Weiyanyihao-Recip on SOD,MDA in rats with chronic atrophic gastritis

作　　者：阮氏秋河[1] 刘友章[1] 

机构地区：[1]广州中医药大学,博士研究生510405

出　　处：《环球中医药》2009年第3期185-187,共3页Global Traditional Chinese Medicine

基　　金：广东省自然科学基金(06024137)

摘　　要：目的观察胃炎一号方对实验大鼠慢性萎缩性胃炎SOD和MDA的影响。方法60只SD大鼠,随机分为6组:模型组、空白阻、胃炎一号方大、中、小剂量组和维酶素组,每组10只。除空白组只给生理盐水灌胃外,其余各组均采用甲基-硝基-亚硝基胍(MNNG)和盐酸雷尼替丁胶囊灌胃建立慢性萎缩性胃炎模型,造模后各组均给予胃炎一号方治疗60天。疗程结束后取血,分离出血清,测定SOD和MDA含量。结果与模型组比较,胃炎一号方3个治疗组血清SOD含量明显升高,血清MDA的含量明显下降(P<0.05或P<0.01),胃炎一号各组之间及胃炎一号各组与维酶素组之间比较无统计学差异。结论胃炎一号可能通过升高血清SOD含量、降低血清MDA含量来实现对慢性萎缩性胃炎的治疗作用。Objective To observe the effects of Weiyanyihao-Recip on SOD, MDA in rats with CAG. Methods 60 SD rats were radomisely devided into 6 groups （ 10 animals in each） ：model group, control group, Weiyanyihao-Recip with high-dose, medium-dose and low-dose group and Weimeisu group. Except the control group received intragastrical administration of normal saline, the rest five groups under-went intragastric MNNG and ranitidine hydrochloride capsules administration to be made into CAG models. Afterwards, corresponding medication was administered to each group for 60 days. Reagent kits of SOD and MDA were employed for biochemical detection of serum. Results Compared to the model group, that of SOD level in the three Weiyanyihao-Recip hao groups significantly higher while the contents of MDA is significantly lower,and the difference was statistically significant（ P 〈 0. 05 or P 〈 0. 01 ）. But, there was no statistical difference between Weiyanyihao-Recip groups and Weimeisu group. Conclusion It is suggested that Weiyanyihao-Recip can increase the level of serum SOD, decrease the content of serum MDA, which maybe contribute to treatment effect on chronic atrophic gastritis rats.

关 键 词：胃炎一号方 慢性萎缩性胃炎 超氧化物岐化酶 丙二醛 

分 类 号：R285.6[医药卫生—中药学]