2型糖尿病并发冠心病患者血清脂联素、TNF-α和hs-CRP检测的临床意义  

Clinical significance of determining levels of serum adiponectin,TNF-α and hs-CRP in patients with DM2 complicated with coronary heart disease(CHD)

作　　者：刘洪书[1] 王恩波[1] 

机构地区：[1]江苏省连云港市第一人民医院检验科,222002

出　　处：《淮海医药》2009年第3期212-213,共2页Journal of Huaihai Medicine

摘　　要：目的探讨2型糖尿并发冠心病患者血清脂联素、TNF-α和hs-CRP水平的变化在糖尿病冠心病发生、发展中的作用。方法分别应用放免法、ELISA法和免疫比浊法对88例糖尿病患者(其中40例并发冠心病,48例无糖尿病并发症患者)进行血清脂联素、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平测定,并与35名正常健康人作比较。结果2型糖尿病并发冠心病患者血清脂联素水平显著低于正常人组(P<0.01),而TNF-α、hs-CRP水平显著高于正常人组(P<0.01),且并发冠心病患者血清脂联素水平明显低于无并发症组(P<0.05),TNF-α、hs-CRP明显高于无并发症组(P<0.05)。结论血清低水平的脂联素和高水平的TNF-α、hs-CRP促进了2型糖尿病的发生与发展。检测糖尿病患者血清脂联素、TNF-α和hs-CRP水平的变化有利于观察病情,对评价疗效及预防并发症具有重要的临床意义。Objective To explore the significance of changes of serum adiponectin,TNF-α and hs-CRP levels in development of coronary heart diseases in patients with type 2 diabetes mellitus. Methods Serum TNF-α （ with RIA ） , adiponectin （with ELISA） ,hs-CRP（with immuno-turbility） contents were measured in： （ 1 ） DM2 patients complicated with CHD, n = 40 and （2） DM2 patients without CHD, n = 48 and 35 controls. Results Serum adiponectin levels were significantly lower in patients complicated with CHD than those in controls （P 〈0.01 ） ,while serum TNF-α,hs-CRP levels were significantly higher than those in controls （ P 〈 0. 01 ） . Furthermore for those DM2 patients complicated with CHD, serum adiponeetin levels were remarkably lower than those in patients whithout CHD （ P 〈 0.05 ）. Conclusion . The lower levels of adiponeetin and higher TNF-α,hs-CRP played an important role in the development of coronary heart diseases. Monitoring those levels might be helpful in the assessment of treatment efficacy and outcome prediction.

关 键 词：糖尿病 2型 冠状动脉疾病 脂联素 肿瘤坏死因子-Α 超敏C反应蛋白 

分 类 号：R587.1[医药卫生—内分泌]