一种合成喹啉-3-羧酸甲酯的新方法  

A New Method of Synthesis of 3-Quinolinecarboxylic Acid Methyl Ester

作　　者：梅苏宁[1] 俞迪虎[1] 李勇[1] 

机构地区：[1]浙江大学材料与化学工程学院,浙江杭州310027

出　　处：《精细化工中间体》2009年第2期41-43,共3页Fine Chemical Intermediates

摘　　要：以喹啉-2,3-二羧酸为原料,经过脱羧、酰氯化和醇解等3步反应来合成喹啉-3-羧酸甲酯,总收率达83.5%。用红外光谱及核磁共振图谱对目标产物进行了结构表征,产物的熔点为74～75℃。讨论并证实了第一步脱羧反应的反应机理。3-Quinolinecarboxylie acid methyl ester was steps of decarboxylation, chlorization and alcoholysis in compound was identified by IR and ^1H NMR. Its melting was discussed. synthesized from quinoline-2,3-dicarboxylic acid in an overall yield of 83.5%. The structure of the target point was 74-75℃. The mechanism of decarboxylation

关 键 词：喹啉-2 3-二羧酸 喹啉-3-羧酸甲酯 脱羧 酰氯化 醇解 

分 类 号：TQ016.1[化学工程]