5-氟-2-羟基苯乙酮的制备  

Improvement on the Prepartion of 5-Fluoro-2-hydroxyacetophenone

作　　者：余卫国[1] 史海波[1] 赵向奎[1] 

机构地区：[1]浙江医药高等专科学校,浙江宁波315100

出　　处：《精细化工中间体》2009年第2期44-46,共3页Fine Chemical Intermediates

基　　金：浙江医药高等专科学校校级科研项目资助(ZPCSR2006005)

摘　　要：以对氨基苯酚为原料,一步进行氨基与酚羟基的双重酯化,三氯化铝/氯化钠条件下进行Fries重排,水解产物进行氟重氮化后加热得5-氟-2-羟基苯乙酮成品。原料廉价,反应条件相对温和,总收率可达54.5%,具有工业生产应用价值。5-Fluoro-2-hydroxyacetophenone was prepared from p-aminophenol in an overall yield of 54.5%. In the first step, both groups of amino and hydroxyl in p-aminophenol were esterificated in one step, followed by Fries rearrangement in the presence of AlCl3/NaCl. The product was then hydrolyzed and fluorin diazotized to give the title product.

关 键 词：5-氟-2-羟基苯乙酮 对氨基苯酚 FRIES重排 氟重氮化 

分 类 号：O621.3[理学—有机化学]