司他夫定、拉米夫定联合奈韦拉平治疗艾滋病患者12例效果评估  

Evaluation on the effects of combined therapy with Stavudine,Lamivudine and Nevirapine in HIV/AIDS

作　　者：洪艳 

机构地区：[1]安徽省监狱局中心医院,安徽合肥230021

出　　处：《安徽预防医学杂志》2009年第2期90-91,111,共3页Anhui Journal of Preventive Medicine

摘　　要：目的观察2种核苷类逆转录酶抑制剂(NRTI)联合1种非核苷类逆转录酶抑制剂(NNRTI)抗逆转录病毒方法治疗艾滋病的效果和不良反应,为艾滋病治疗提供依据。方法用3TC、D4T联合NVP治疗12例艾滋病患者,随访1年。随访指标为定期检测CD4T淋巴细胞计数,常规生化检查和不良反应。结果12例患者在治疗1年后临床症状明显改善,CD4细胞计数和CD4/CD8比例逐渐升高,且差异有统计学意义。治疗初期不良反应有胃肠道反应、中枢神经系统症状及周围神经病变,一般可自行缓解。结论该药物组合疗效显著,能降低艾滋病患者的机会性感染,提高其生活质量,并能使部分免疫功能得以重建,具有较高的安全性和耐受性。Objective To observe the safety and efficacy of the anti - retroviral therapy with 2NRTI and 1NNRTI. Methods 12 cases of HIV infections and AIDS patients were treated with Stavudine, Lamivudine and Nevirapine. All cases were followed up for i year. Follow - up indicators for the regular test CD4T cell count, the conventional biological and chemical inspections and adverse reactions. Result Clinical symptoms of 12 cases improved significantly during 1 year＇ s treatment. The CD4 counts and the CD4/CD8 rates increased gradually （ from （ 118.83 ± 88.72） /mm3 , （ 0. 16 ± 0. 14） / mm3 to（ 284.6 ± 169.47 ） /mm3 , （ 0.34 ±0. 23 ） /mm3 ）, and there was statistic significance between before and after treatment. Adverse reactions included gastrointestinal reactions, central nervous system symptoms, and peripheral neuropa- thy in the initial treatment, Most of them did not need treatment and disappeared gradually. Conclusion The treatment with Stavudine, Lamivudine and Nevirapine could decrease viral load remarkably and rapidly, could reduce the chance of AIDS infection, improve their quality of life and reestablish immunologic function of same patients, and had a high safety and tolerance.

关 键 词：艾滋病 治疗效果 司他夫定 拉米夫定 奈韦拉平 

分 类 号：R512.91[医药卫生—内科学]