125株嗜麦芽窄食单胞菌感染的临床和耐药性分析  

Clinical Feature and Antibiotic Resistance Analyse of 125 Cases of Infection Caused by Stenotrophomonas Maltophilia

作　　者：曹菊[1] 

机构地区：[1]凉山州第一人民医院,四川西昌615000

出　　处：《新医学导刊》2009年第4期21-23,共3页New Medical Science

摘　　要：目的了解嗜麦芽窄食单胞菌感染的临床特点及对抗生素的耐药性。方法回顾性分析2006～2008年我院分离的嗜麦芽窄食单胞菌的耐药性以及所致感染病例的临床特点。结果共发现125例感染病例，全部符合医院感染诊断标；隹，以呼吸道感染为主。易感因素主要是接受侵入性操作，长期应用免疫抑制和广谱抗生素等。药敏结果显示125株嗜麦芽窄食单胞菌对多种抗生素耐药率较高，仅对甲氧苄啶／磺胺甲嚷唑、环丙沙星、替卡西林／克拉维酸、多粘菌素E耐药率较低，分别为11％、29％、12％、23％。结论加强环境消毒和控制广谱抗生素应用可有效降低嗜麦芽窄食单胞菌引起的医院感染的发生，甲氧苄啶／磺胺甲嗯唑、环丙沙星、替卡西林／克拉维酸可作为抗感染治疗的一线用药。Objective To investigate the clinical features of infections caused by Stenotrophomonas maltophilia and its antibiotic resistance. Methods Stenotrophomonas Maltophilia strains Isolated from 2006 to 2008 were retrospectively surveyed for its antibiotic resistant rates and clinical infection characters. Results For the total 125 cases of infections, all of them accorded with the diagnostic standard of nosocomial infection and the most of them were respiratory infection. The main risk factors of Stenotrophomonas maltophilia infections were accepting invasive operation and long - time using of immune suppressing reagents and extended - spectrum antibiotics. The results of antibiotic sensitive tests exhibited that Stenotrophomonas maltophilia was multible - resistant to tested antibiotics and sensitive to ciprofloxacin, sulfamethoxazole, ticarcillin/clavulanic, eolistin, the resistant rates were 11%, 29%, 12% , 23% respectively. Conclusions Enhancing environment sterilizing and control the using of extendedspectrum antibiotics contribute to decreasing nosocomial infection caused by Stenotrophomonas maltophilla. Sulfamethoxazole, eiprofloxacin and ticarcillin/ctavulanic were recommended as the first line antibiotics for treating Stenotrophomonas maltophilia infections.

关 键 词：嗜麦芽窄食单胞菌 临床特点 耐药性 医院感染 

分 类 号：R978.1[医药卫生—药品]