肾康灵治疗小儿频复发性肾病与神经内分泌免疫网络关系的临床研究  

Clinical Research on the Effect of Shenkangling Decoction on Frequently Relapsed Nephrotic Syndrome of Children

作　　者：郑健[1] 艾斯[1] 林青[1] 褚克丹[1] 魏金花[1] 

机构地区：[1]福建中医学院第一临床医学院儿科

出　　处：《中医杂志》2009年第4期311-313,316,共4页Journal of Traditional Chinese Medicine

基　　金：福建省自然科学基金资助项目(C0440015)

摘　　要：目的观察益肾活血中药肾康灵治疗小儿频复发性肾病(FRNS)血核因子-κB(NF-κB)、血和尿血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)的变化,阐明FRNS患儿的发病机理及肾康灵干预治疗的可能机制。方法收集FRNS患儿60例,采用简单随机法分成治疗组30例、对照组30例。观察FRNS患儿治疗前后血NF-κB、血和尿TXB2、6-keto-PGF1α、皮质醇、24h尿蛋白、血总蛋白(TP)、白蛋白(ALB)、总胆固醇(TC)、甘油三酯(TG)等变化。结果治疗组在降低血NF-κB、血和尿TXB2、血6-keto-PGF1α、血和尿TXB2/6-keto-PGF1α比值和提高血浆皮质醇方面明显优于对照组(P<0.01或P<0.05)。结论肾康灵治疗FRNS患儿的作用机制可能与调节NEI网络功能,改善血液高凝状态有关。Objective To observe the changes of nuclear factor-kappa B （NF-κB） of plasma, thromboxane B2（TXB2）, and 6-keto- PGF1α of plasma and urine in children with frequently relapsed nephrotie syndrome （FRNS） treated by Sbenkangling Decoction （Herbal medicines for kidney diseases） which functions to reinforce kidney and activate blood to study the pathogenesis of FRNS and the functional mechanism of Shenkangling. Methods The 60 children cases with FRNS were randomly divided into treatment group and control group, 30 in each. The changes of plasma NF-κB, blood and urine TXB2, 6-keto-PGF1α, hydroeortisone, urine protein of 24 hours, serum total protein （TP）, albumin （ALB）, total cholesterol （TC） and triglyeeride （TG） before and after treatment were observed. Results In decreasing NF-κB, blood and urine TXB2, 6-keto-PGF1α, and TXB2/6-keto-PGF1α and increasing plasma hydrocortisone, the effect of treatment group was significantly better than that of control group （P〈0.01 or P〈0.05）. Conclusion The mechanism of Shenkangling in treatment of FRNS is possibly related to regulation of NEI and the improvement of hypercoagulative state of blood.

关 键 词：小儿频复发性肾病 神经内分泌免疫网络系统 肾康灵 核因子-κB 血栓素B2 6-酮-前列腺素 

分 类 号：R272[医药卫生—中医儿科学]