SLE患者血清抗β_2-糖蛋白Ⅰ抗体与抗心磷脂抗体亚型水平及关系  

Levels of anti-β_2-glycoprotein Ⅰ antibody and anticardiolipin antibody in serum of patients with systemic lupus erythematosus and their relationship

作　　者：黄海霞[1] 张文辉[1] 吴莲凤[1] 朱丽青[1] 潘钦石[1] 

机构地区：[1]温州医学院第一附属医院实验诊断中心,浙江温州325000

出　　处：《中国卫生检验杂志》2009年第4期855-857,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的:探讨SLE患者抗β2GPⅠ抗体及抗心磷脂抗体亚型与血脂水平和凝血酶原时间之间的关系。方法:收集2006年8月至2007年1月我院确诊的SLE患者血液标本41例,采用ELISA法测定血清中ACA亚型及aβ2GPⅠ水平,同时检测ds-DNA、TG、CH、APTT、PT等相关指标。结果:⑴41例SLE患者中aβ2GPⅠ升高者10例(24.4%),ACA-IgG阳性者20例(48.8%),ACA-IgA阳性者7例(17.1%),与正常对照组比较差异均有显著性意义(P分别<0.001或<0.05);⑵10例aβ2GPⅠ阳性SLE患者中有4例同时存在ACA阳性,其中3例为同时ACA-IgG、ACA-IgA阳性,1例为ACA-IgG阳性。41例SLE患者aβ2GPⅠ阳性率与ACA-IgG、ACA-IgA比较差异无显著性意义(P均>0.05);⑶伴有继发性磷脂综合征的SLE和无继发性磷脂综合征SLE患者相关指标的比较,差异均无显著性意义(P均>0.05);⑷41例SLE患者ds-DNA、TG、CH、APTT、PT与aβ2GPⅠ和ACA亚型进行相关性分析,结果CH与ACA-IgA存在正相关,r=2.66,P<0.05;APTT与ACA-IgG存在负相关,r=-0.313,P<0.05。结论:结果提示抗β2GPⅠ抗体可作为SLE继发APS的诊断指标,联合ACA检测将会提高检测率。Objective ：To compare the serum levels of anti - β2 - glycoprotein Ⅰ antibody （ aβ2 GP Ⅰ ） and anticardiolipin anti- body（ACA） with that of anticardiolipin antibodies in SLE patients with secondary anti- phospholipid syndrome and without SAPS. Methods：Forty -one SLE patients and fifty nomal control persons were studied. Serum aCL antibodies and antii - β2 -gly- coprotein I antibody were measured by ELISA. Resdts ： 24. 4% of the patients in SLE group had much higher serum level of aβ2GP Ⅰ and ACA than control group（ P 〈0. 01 ）, There are 4 patients had higher serum level of aβ2GP Ⅰ and ACA meanwhile of 10 patients with SLE. There are negative correlation between ACA - IgG and APTT （r = -0. 313, P 〈 0. 05 ）, positive correlation between ACA - IgA and CH （ r = 2. 66, P 〈 0. 05 ）. Conclusion ： Anti - β2 GP Ⅰ antibody could be a diagnositic marker for SLE - APS, it would be more sensitive if it combined ACA.

关 键 词：系统性红斑狼疮 抗心磷脂抗体 抗β2-糖蛋白Ⅰ抗体 

分 类 号：R593.24[医药卫生—内科学]