OSAHS患者气道内正压通气治疗后血管内皮功能的变化  

Effect of Treatment of Continuous Positive Airway Pressure on Vascular Endothelial Function in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

作　　者：林玲[1] 壮可[1] 乌若丹[1] 吕云辉[2] 杨瑞安[2] 赵燕[1] 张宏[1] 

机构地区：[1]云南省第一人民医院心内科,昆明650032 [2]云南省第一人民医院呼吸内科,昆明650032

出　　处：《中国医药导刊》2009年第3期355-356,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨阻塞性睡眠呼吸暂停综合征(OSAHS)患者气道内正压通气治疗后血管内皮功能的变化。方法:根据多导睡眠呼吸监测仪监测结果。选择年龄、性别、体重指数(BMI)无明显差异的OSAHS患者45例和健康者40例,采用超声检测血管内皮功能进行比较,给予OSAHS组气道内正压通气(CPAP)治疗三个月后再次复查血管内皮功能,并与治疗前进行比较,以观察血管内皮功能的变化。结果:OSAHS组患者血流介导的血管舒张(FMV)较健康对照组明显降低(P<0.05),给予CPAP治疗三个月后,OSAHS组FMV较治疗前明显升高(P<0.05)。结论:OSAHS组患者存在血管内皮功能障碍(ECD),CPAP治疗可改善OSAHS患者的血管内皮功能。Objective： To investigate the effect of continuous positive airway pressure（cPAP） on the endothelial function in patients with obstructive sleep apnea hypopnea syndrome（OSAHS）.Methods： 45 patients with OSAHS examined by polysomnography and 40 healthy subjects were recruited without difference in age, sex and BMI. OSAHA group were treated by cPAP for three months. The vascular endothelial function was redetected by ultrasound after treatment. Results： The flow-mediated vasodilation（FMV） of OSAHS group were significantly lower compared with control group（P〈0,05）. After treatment of cPAP for three months, FMD of OSAHS group were higher significantly（P〈0.05）, Conclusions： cPAP therapy could improve the vascular endothelial function which was impaired in patients with OSAHS.

关 键 词：OSAHS 气道内正压通气 血管内皮功能 

分 类 号：R766.43[医药卫生—耳鼻咽喉科] R563.8[医药卫生—临床医学]