舒芬太尼联合氯诺昔康用于开胸术后静脉镇痛  

Clinical Observation of Sufentanil combined with LornOXicam For Patient Controlled Intravenous Analgesia after Thoracotomy Conclusion

作　　者：彭沛华[1] 梁荣毕[1] 高红林 秦婷婷[1] 

机构地区：[1]云南昆明医学院第一附属医院麻醉科,昆明650031 [2]云南省元江县人民医院麻醉科,元江650013

出　　处：《中国医药导刊》2009年第3期421-422,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:对舒芬太尼联合氯诺昔康在开胸患者术后自控静脉镇痛(PCIA)的效果作出评价。方法:60例ASAⅠ或Ⅱ级开胸术后患者随机分为Ⅰ组和Ⅱ组,各30例,两组均于清醒拔管后接PCIA泵,Ⅰ组用药为舒芬太尼125 μg、Ⅱ组为舒芬太尼75μg+氯诺昔康24mg。观察术后2h、6h、1h、24h、48h镇痛视觉模拟(VAS)评分、镇静评分、镇痛药液用量及舒芬太尼用量、动脉血氧分压(PaO_2)及二氧化碳分压(PaCO_2),不良反应发生情况。结果:两组各时点VAS评分,PaO_2,以及12h、24h、48h镇痛药用量差异无统计学意义;各时点镇静评分、PaCO_2、舒芬太尼用量Ⅱ组小于Ⅰ组,2h、6h镇痛药用量Ⅱ组多于Ⅰ组。Ⅰ组出现头晕、嗜睡、皮肤瘙痒等不良反应的比例高于Ⅱ组,但差异无统计学意义。结论:舒芬太尼联合氯诺昔康用于开胸术后静脉镇痛安全、有效。Objective： To evaluate the efficiency of Sufentanil combined with LornOXicam in Patient Controlled Intravenous Analgesia （PCIA） after thoracotomy. Methods： Sixty ASA I or II patients undergoing elective thoracotomy were divided randomly into two groups（thirty cases in each group）. Group I ： Sufentanit 125μg.Grooup II ： Sufentanil 125μg＋ LornOXicam 24mg. All of patients accepted PCIA after recovery from general anesthesia and tracheal extubation.The effect of postoperative analgesia was assessed by recording visual analog scale （VAS）,sedation scale,the consumed dosage of the total analgesics and Sufentanil at 2h,6h,12h,24h,48h separately after operation, as well as arterial partial pressure of OXygen （PaO2） , arterial partial pressure of Carbon DiOXide （PaCO2） , additional side effects, Results： There were no difference between the two groups on the sides ofVAS, PaO2 at all the time points and the total analgesic dosage at 12h,24h,48h ; There was more total analgesic consumption in group II at 2h;6 h, group II showed less sedation scale, PaCO2, dosage of Sufentanil than group I at all the time points ; Incidence rate of adverse reaction in group I were higher than group II ,but there was no statistical significance between the two groups. Conclusions： The method of Sufentanil combined with LornOXicam for Patient Controlled Intravenous Analgesia after thoracotomy is safety and effective.

关 键 词：舒芬太尼 氯诺昔康 静脉镇痛 开胸于术 

分 类 号：R655[医药卫生—外科学]