阿奇霉素静脉滴注治疗急性咽喉炎致失眠  

Insomnia following intravenous infusion of azithromycin for acute laryngopharyngitis

作　　者：国玉芝[1] 季芳茹[1] 田寅[1] 

机构地区：[1]佳木斯大学附属第一医院药剂科,黑龙江佳木斯154002

出　　处：《药物不良反应杂志》2009年第2期122-122,共1页Adverse Drug Reactions Journal

摘　　要：1例35岁女性患者,因患急性咽喉炎给予阿奇霉素0.5g加入5%葡萄糖注射液250ml静脉滴注,1次/d。当晚出现入睡困难。次日静脉滴注后又出现入睡困难,给予安神片5片及地西泮10mg口服,失眠症状仍未改善。停用阿奇霉素,改用左氧氟沙星100ml静脉滴注,1次/d,1d后睡眠恢复正常。追问病史,患者1年前使用阿奇霉素治疗,曾出现过失眠。A 35-year-old woman received an IV infusion of azithromycin 0.5 g dissolved in 250 ml of glucose injection 5% once daily for acute laryngopharyngitis. The woman experienced difficulty falling asleep at night. The next day, the same symptom reappeared after infusion. She was administered with 5 Anshen tablets, followed by oral diazepam 10 rag, but her insomnia did not improve. Azithromycin was withdrawn and switched to an IV infusion of levofloxacin 100ml once daily. Her sleep normalized one day later. A review of her medical history showed that she had developed insomnia after azithromycin treatment one year before.

关 键 词：阿奇霉素 失眠 不良反应 

分 类 号：R595.3[医药卫生—内科学]