硝苯地平致严重剥脱性皮炎  

Nifedipine-induced severe exfoliative dermatitis

作　　者：孟小斌[1] 曾黄辉[1] 林建昌[1] 

机构地区：[1]广东省梅州市人民医院药剂科,广东梅州514031

出　　处：《药物不良反应杂志》2009年第2期136-136,138,共2页Adverse Drug Reactions Journal

摘　　要：1例87岁老年女性患者因高血压自行服用硝苯地平10mg,3次/d。第2天,患者颈、躯干、腹背出现潮红伴瘙痒,四肢肿胀及体温升高。入院查体:T38℃,R98次/min;局部皮肤出现脱屑,占体表面积1/4。实验室检查:WBC17.5×109/L,中性粒细胞数14.8×109/L。诊断为药物性剥脱性皮炎。给予左西替利嗪、葡萄糖酸钙、西米替丁、地塞米松治疗。8d后患者T36.8℃,R20次/min,WBC9.7×109/L,中性粒细胞数8.25×109/L,皮肤潮红、瘙痒减轻,肢体胀肿消退而出院。An 87-year-old woman took nifedipine 10 mg three times daily herself for hypertension. The next day, the patient developed flush with pruritus on her neck, trunk, abdomen and back, swelling of her extremities, and increased body temperature. After admission, an examination showed that her body temperature was 38℃, her respiratory rate was 98 breaths/min; her local skin presented with desquamation, and one-fourth of her body-surface was involved. Laboratory testing revealed the following： WBC count 17. 5×10^9/L, neutrophil count 1 4.8×10^9 / L. Drug - induced exfoliative dermatitis was diagnosed. Levocetirizine, calcium gluconate, cimetidine, anddexamethasone were given. Eight days later, her examination showed a temperature of 36.8℃, a respiratory rate of 20 breaths/min, a WBC count of 9.7 ×10^9/L, and a neutrophil count of 8.25 ×10^9/L. His flush and pruritus improved and the swelling of extremities subsided, then she was discharged.

关 键 词：硝苯地平 剥脱性皮炎 不良反应 

分 类 号：R595.3[医药卫生—内科学]