2,3,4,5--双(-邻1,10-亚癸基)-呋喃的合成  

A Concise Synthesis of 2,3,4,5-Bis(ortho-1,10-decylidene)furan

作　　者：杜士杰[1,2] 刘建平[2] 李太公[2] 王明安[2] 

机构地区：[1]河北北方学院农林科技学院,河北张家口075131 [2]中国农业大学理学院,北京100194

出　　处：《河北北方学院学报（自然科学版）》2009年第2期25-28,32,共5页Journal of Hebei North University:Natural Science Edition

基　　金：国家自然科学基金资助项目(20072053)

摘　　要：目的对文献报道的两个合成1,1'-双环十二-2,2'-二酮方法进行了再研究.方法以环十二酮的烯胺和卤代酮反应制备标题化合物.结果合成了1,1'-双环十二-2,2'-二酮的脱水关环产物2,3,4,5-双-(邻-1,10-亚癸基)-呋喃.结论反应产物非常复杂,从中意外的获得了其关环产物.Objective Two synthetic methods of 1, 1′-bicyclododecyl-2, 2′-dione in literature were reinvestigated. Methods The other route for 1, 1′-biscyclododecan-2, 2′-dione synthesis by the alkylation of enamine with halogenated ketone was carried out. Results The dehydration and cyclization product 2, 3, 4, 5-bis （ortho-1, 10- decylidene） furan was obtained. Its structure was confirmed by 1H, 13C NMR, ESI-MS, and IR spectral data. Conclusion The productions are very complex and unexpectedly obtained cyclization product.

关 键 词：1 1′-双环十二-2 2′-二酮 2 3 4 5-双-(邻-1 10-亚癸基)-呋喃 环十二内酯 1 2-环十二二酮 12-羟基十二酸酐 

分 类 号：O622.4[理学—有机化学]