颅脑损伤患者血清C-反应蛋白和血糖水平的动态变化及其意义  

Clinical significance of dynamic changes of C-reaction protein and glucose in patients with traumatic brain injury

作　　者：蔡朝民[1] 曹建华[1] 陈群蓉[1] 李宏伟[1] 

机构地区：[1]广东省深圳市宝安区人民医院/南方医科大学附属宝安医院,518101

出　　处：《检验医学与临床》2009年第9期650-651,共2页Laboratory Medicine and Clinic

摘　　要：目的研究颅脑损伤患者血清C-反应蛋白(CRP)、血糖(Glu)水平的动态变化及其意义。方法97例颅脑损伤患者按照病情计分法分为重型组(29例)、中型组(31例)、轻型组(37例)3组,35例健康体检者为健康对照组。用生化分析仪测定颅脑损伤患者伤后6h、1d、3d、14d血清中CRP、Glu水平。结果颅脑外伤患者伤后6h血清CRP、Glu含量均有不同程度升高,与健康对照组比较差异均有统计学意义(P<0.01)。颅脑损伤患者CRP和Glu水平与患者入院时的GCS评分呈负相关,与其病情呈正相关,重型组患者血清CRP、Glu升高最为明显;中型和轻型组次之,3组之间的差异有显著性;病情重和预后差的患者其CRP、Glu水平升高幅度大且持续时间更长。结论血清CRP、Glu水平监测可作为颅脑损伤严重程度评价的指标,动态观察颅脑外伤患者血清CRP、Glu水平对疗效观察和预后判断具有重要价值。Objective To study the clinical values of the dynamic changes of serum C-reaction protein（CRP） and glueose（Glu） in the patients with traumatic brain injury. Methods 97 cases of traumatic brain injury were divided into three groups（gentle,miled, moderate and severe） based on the GCS scores, and 35 cases of healthy people were used as controls. The concentrations of CRP and Glu in serum were determined by biochemical analyzer at 6 h, on 1 d,3 d,14 d after injury. Results The levels of serum CRP and Glu were significantly higher in traumatic brain injury group than those in control group（P〈0.01） ,and had a negative correlation with the patients＇ GSC scores. The increased concentration of CRP and Glu were highest in severe group than those in moderate and mild group. The increased range of CPR and Glu in patients with worsen condition and malignant prognosis was higher and the time of duration was longer. Conclusion The levels of serum CRP and Glu are related to the severity of patients with traumatic brain injury,and the dynamic observation of CRP and Glu changes can be used to judge the severity and prognosis in the patients with traumatic brain injury.

关 键 词：颅脑外伤 C-反应蛋白 血糖 预后 

分 类 号：R619[医药卫生—外科学] R587.1[医药卫生—临床医学]