Graves病患者血清TNF-α的变化及其相关因素的分析  

Serum TNF-α Changes of Patients with Graves Disease and Analysis of Correlation Factors

作　　者：茹仙古丽.吾买尔 哈丽亚.哈力木别克[1] 巴雅[1] 赵金萍[1] 

机构地区：[1]新疆医科大学第一附属医院核医学科,乌鲁木齐830054

出　　处：《地方病通报》2009年第2期19-20,共2页Endemic Diseases Bulletin

摘　　要：目的探讨肿瘤坏死因子(TNF-α)与格雷夫斯病/Graves病(GD)的关系。方法100例GD患者根据病史分为GD初发组和复发组,于治疗前用放射免疫法检测外周血清TNF-α浓度变化,并与血清FT3,FT4,TPOAb,TGAb进行相关性分析。结果GD患者血清TNF-α显著高于对照组,血清TNF-α水平与FT3,FT4水平无相关性。结论TNF-α参与了GD的发生、发展过程。Objective To study the relationship between the serum tumor necrosis factor （ TNF -α ） and Graves disease （ GD ）. Methods Using the method of radioimmunoassay, the levels of TNF-α in serum of 100 patients were measured before therapy. Results The levels of TNF -α of GD patients were significantly higher than those of the control group （ t = 3.73, 2. 80, P 〈 0. 05 ）. Conclusions TNF -α plays certain roles in the progressing of GD.

关 键 词：格雷夫斯病/Graves 肿瘤坏死因子 

分 类 号：R581.1[医药卫生—内分泌]