清气凉营注射液对风温肺热病患者血清促炎、抗炎因子的调节作用  

The Qingqiliangying Injection Interventional Study of Serum Pro-inflammatory and Anti-inflammatory Cytokines in Patients with Wind-heat in Lung Syndrome

作　　者：赵颖[1,2] 熊旭东[2] 

机构地区：[1]第二军医大学附属长征医院,上海200003 [2]上海中医药大学附属曙光医院,上海200021

出　　处：《中国中医急症》2009年第5期673-675,共3页Journal of Emergency in Traditional Chinese Medicine

摘　　要：目的观察清气凉营注射液对风温肺热病(热在肺卫证)患者体内血清促炎及抗炎因子的调节作用及机制。方法将风温肺热病(热在肺卫证)60例患者随机分为两组,治疗组给予清气凉营注射液静滴,对照组予以双黄连注射液静滴,疗程均为3d;比较两组疗效及血清促炎、抗炎因子的变化情况。结果治疗组疗效优于对照组,其血清促炎因子(TNF-α、IL-6、IL-8)下降幅度及抗炎因子(IL-4、IL-10)上升幅度均大于对照组。结论清气凉营注射液作用机制可能与其调节细胞因子、平衡促炎/抗炎因子有关。Objective： To observe the regular effect of Qingqiliangying Injection on the pro - inflammatory cytokines and the anti - inflammatory cytokines in patients with wind - heat in lung syndorme. Methods： 60 patients with wind - heat in lung syndorme were randomly divided into two groups. The treatment group took Qingqiliangying Injection,and the control group took Shuanghuanglian Injection for 3d. Before and after treatment, concentrations of the pro- inflammatory and the anti- inflammatory were carried out in both groups. Results： Compared with the control group, the level of the pro - inflammatory cytokines（TNF-α, IL - 6, IL - 8） decreased and the level of the anti -inflammatory cytokines（IL -4, IL - 10） increased significantly in the treatment group. Conclusion： The mechanisms of action in Qingqiliangying Injection could be related to its adjusting process of cell factors and balancing effect of pro -/anti - inflammatory cytokines.

关 键 词：风温肺热病 促炎因子 抗炎因子 清气凉营注射液 

分 类 号：R254.9[医药卫生—中医内科学]