大理市新生儿脐血乙肝病毒感染的基因型分布研究  

DISTRIBUTION OF HEPATITIS B VIRUS GENOTYPES IN NEONATAL UMBILICAL CORD BLOOD IN DALI OF YUNNAN PROVINCE

作　　者：朱任坚[1] 申元英[2] 陈钟[1] 王涛[2] 杨晓霞[3] 

机构地区：[1]大理学院临床医学院,大理671000 [2]大理学院基础医学院 [3]大理学院生命科学与化学

出　　处：《现代预防医学》2009年第9期1739-1740,共2页Modern Preventive Medicine

基　　金：国家自然科学基金资助项目(30560136);云南省中青年学术技术带头人后备人才培养基金项目(2006py01-57)

摘　　要：[目的]探讨乙型肝炎病毒(HBV)母婴垂直传播的主要基因型分布特点,为预防和阻断HBV的母婴传播提供依据。[方法]对HBsAg阳性孕产妇脐血进行乙肝病毒基因型检测。[结果]脐血HBVDNA阳性23例(32.9%),基因型主要为B、B+C、C型,分别为11例(43.5%)、8例(34.8%)和4例(21.7%)。[结论]该地区HBV垂直感染的基因型分别是B型、B+C型和C型。[Objective] To investigate the distribution characteristics of hepatitis B virus （HBV） genotypes in vertical transmission in Dali of Yunnan Province. [Methods] A total of 70 samples of sera from pregnant women who infected with HBV were collected for the detection of HBV genotypes by genotype-specific primers. Meanwhile, their umbilical cord blood were collected and detected. [Results] 23 cases had positive HBV DNA in their umbilical cord blood （32.9%）, in which the proportion of genotype B, B＋C and C was 43.5%, 34.8% and 21.7%, respectively. [Conclusion] Genotype B, mixed genotype （B＋C） and genotype C are major HBV genotypes in vertical infection with HBV in Dali of Yunnan Province.

关 键 词：乙型肝炎病毒 基因型 多聚酶链反应 脐血 垂直传播 

分 类 号：R512.62[医药卫生—内科学]