胰岛素治疗逆转糖尿病小鼠肝脏的脂肪沉积  

Insulin reverses fatty liver disease in diabetic mice induced with high fat diet

作　　者：朱延华[1] 陈香[1] 李明[1] 余秋琼[1] 孙卫平[1] 毕艳[1] 翁建平[1] 

机构地区：[1]广州中山大学附属第三医院内分泌科,510630

出　　处：《中华内分泌代谢杂志》2009年第2期200-202,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：基金项目：国家973项目“2型糖尿病发病机制和营养于预的代谢组学研究”（2006CB503902）

摘　　要：观察胰岛素治疗对糖尿病小鼠脂肪肝的影响。C57BL／6J小鼠高脂饲养12周后，甘精胰岛素皮下注射4周。结果显示，与高脂组相比，胰岛素组腹腔葡萄糖耐量试验所有时间点血糖及血总胆同醇、甘油三酯（TG）均显著改善（P〈0．05）；病理显示肝脏空泡样变性明显减少，肝脏TG降低20．71％（P〈0．05）。提示胰岛素治疗能改善高脂饮食诱导小鼠的脂肪肝。The effect of insulin treatment on fatty liver was investigated in diabetic mice fed with high-fat diet. C57BL/6J mice were fed with high fat diet for 12 weeks, and then treated with Glargine for 4 weeks. The results showed that during intraperitoneal glucose tolerance test, blood glucose, serum total cholesterol and triglyceride （TG） were significantly lower in insulin-treated high fat group than those in untreated ones （P 〈 0.05 ）. The hepatic histology showed minimal or barely visible fat in hepatic ceils along with TG content in liver decreasing by 20.71%. The results suggest that insulin ameliorates hepatic intracellular lipid accumulation induced by high fat diet.

关 键 词：脂肪肝 糖尿病 甘精胰岛素 

分 类 号：R587.1[医药卫生—内分泌] R223.11[医药卫生—内科学]