血管紧张素受体阻断剂对高脂诱导的胰岛素抵抗大鼠脂肪组织NF—κB、PPARγ表达的影响  

Effect of angiotensin receptor blocker on the expressions of NF-κB and PPARγ in adipose tissue of high-fatdiet induced insulin resistant rats

作　　者：刘晓玲[1] 袁莉[1] 郭彩红[1] 黄艳[1] 杜爱民[1] 张利莉[1] 

机构地区：[1]华中科技大学附属协和医院内分泌科,武汉430022

出　　处：《中华内分泌代谢杂志》2009年第2期210-211,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：基金项目：湖北省自然科学基金资助（No：2005ABA185）

摘　　要：胰岛素抵抗大鼠脂肪组织中NF-κB、PPARγ表达增加，血管紧张素受体阻断剂可降低脂肪组织NF-κB蛋白表达21％，增加PEARγ蛋白表达28％，减小脂肪细胞体积，这可能是阻断肾素血管紧张素系统改善肥胖脂肪组织炎症和胰岛素抵抗的分子机制之一。The expressions of NF-κB and PPARγ were increased in adipose tissue of insulin resistant rats. The angiotensin receptor blocker decreased NF-κB protein expression by 21% , increased PPARγ protein expression by 28% and diminished adipocyte size, suggesting that these findings may be involved in the improvement of obesity-induced inflammation and insulin resisitance.

关 键 词：过氧化物酶体增殖物激活受体Γ NF—κB 血管紧张素受体阻断剂 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]