药物性肝炎196例临床分析  

Clinical analysis of 196 cases of drug-induced hepatitis

作　　者：俞秀丽[1] 过建春[1] 石伟珍[1] 谢蕾[1] 岑立冲[1] 

机构地区：[1]杭州市第六人民医院中西医结合科,310014

出　　处：《国际流行病学传染病学杂志》2009年第2期95-97,共3页International Journal of Epidemiology and Infectious Disease

摘　　要：目的分析196例药物性肝炎患者的临床资料，为临床安全用药提供帮助。方法回顾性分析196例药物性肝炎患者的临床表现、致病药物种类、药物引起肝损害的出现时间以及各型药物性肝炎的ALT水平特点。结果引起药物性肝炎的药物种类众多，其中中药占了很高比例（91／196，46．43％）。本组药物性肝炎中肝细胞型59例、胆汁淤积型69例和混合型68例。结论了解药物性肝炎的特点，有助于提高临床医师对药物性肝炎的认识，提高临床用药的安全性。Objective To analyse the clinical data of 196 cases of drug-induced hepatitis and to improve the medication safety in clinical practice. Methods Retrospective analysis on the clinical manifestations, species of drugs inducing liver injury, time interval of drug application and liver injury, features of ALT level in 196 cases of drug-induced hepatitis. Results Species of drugs inducing hepatitis were diverse, and among the total, Chinese herbal drugs were very common（91/196,46.43% ） .There were 59 cases of hepatocyte-injury type, 69 cases of cholestasis type and 68 cases of mixed type in this drug-induced hepatitis group. Conclusions Understanding the features of drug-induced hepatitis is helpful to improve the medication safety in clinical practice.

关 键 词：肝炎 慢性 药物性 中药 重型肝炎 

分 类 号：R595.3[医药卫生—内科学]