巴马亭与白蛋白相互作用研究  

Studies on Interaction of Palmatine with Human Serum Albumin

作　　者：张立伟[1] 赵春贵[1] 董光华 杨频[1] 

机构地区：[1]山西大学分子科学研究所

出　　处：《山西大学学报（自然科学版）》1998年第2期144-146,共3页Journal of Shanxi University(Natural Science Edition)

摘　　要：利用荧光光谱法对巴马亭与人血清白蛋白的相互作用进行了研究。基于药物白蛋白荧光猝灭机理，得出了药物与白蛋白结合常数；根据能量转移理论，估算了巴马亭与白蛋白结合位点。Palmatine is the main effective component of the Jatrorrhinepalmata Miers, which has been widely used in clinic treatment as effective antibactera. When a medicine enters the body, it always goes into the acceptor site and has pharmacodnamic action by way of storage and carriage of plasma. Serum albumin is the major serum protein, which can combine with many inner and outer source compound. in this paper, the interaction of palmatine with Albumin has been strdied by fluorescence method and their binding constant and distance of donor-acceptor is obtained.

关 键 词：巴马亭 人血清白蛋白 荧光法 防已科 

分 类 号：Q949.746.9[生物学—植物学]