基于活塞挤出的组织工程支架低温沉积制造工艺  

Low temperature deposition based on piston-extrusion for fabricating tissue engineering scaffolds

作　　者：金乐[1] 熊卓[1] 刘利[1] 颜永年[1] 张人佶[1] 

机构地区：[1]清华大学机械工程系,北京100084

出　　处：《清华大学学报（自然科学版）》2009年第5期652-655,659,共5页Journal of Tsinghua University(Science and Technology)

基　　金：国家自然科学基金资助项目(50675108)

摘　　要：快速成形(RP)工艺可实现个性化制造和可控的材料、结构组成,因此在组织工程中得到广泛应用。该文设计开发基于活塞挤出的材料喷头,对挤出工艺进行探讨与研究,提出采用压力自释放方案解决其流涎问题,并将其应用于低温沉积制造(LDM)工艺。实验表明,基于活塞挤出的LDM工艺可以成形组织工程支架,并且具有广泛的材料适应性,可成形多种生物材料,尤其可成形其他RP工艺难于成形的胶原材料。Rapid prototyping （RP） processes are widely used in tissue engineering, to produce customized designs with good controllability of scaffold materials and structures. Paper describes a piston extrusion nozzle for low-temperature deposition manufacturing （LDM） developed to form scaffolds. A pressure-release solution was developed to stop the leakage from the nozzle to improve scaffold quality. The process can form a wide range of materials including collagen which is hard to form by other RP processes.

关 键 词：组织工程支架 低温沉积 活塞挤出喷头 胶原 

分 类 号：TH16[机械工程—机械制造及自动化]